1 capsule. 500 contains 500 mg of calcium carbonate (200 mg Ca +2); 1 capsule. 1000 includes 1 g of calcium carbonate (400 mg Ca +2). Excipients: magnesium stearate, talc, titanium dioxide, indigo carmine, sodium lauryl sulfate, sulfur dioxide, purified water, gelatin.Action: Calcium is an essential mineral component affecting to maintain the electrolyte balance of the body and the proper functioning of numerous regulatory mechanisms. It is necessary in such processes, and include neuromuscular, muscle function, normal development of the skeletal system, blood clotting, activation of certain enzymes, the permeability of cell membranes and blood.Calcium carbonate is converted under the influence of the gastric juice HCl, calcium chloride, which is absorbed from the small intestine. Administration of supplements of calcium deficiency in the body, helps meet the daily need for calcium, reduces the loss of calcium from the bones in women in peri- and postmenopausal women and in the elderly. In patients with chronic renal calcium prevents the development of renal osteodystrophy due to reduced phosphate absorption from the gastrointestinal tract. In addition, calcium ions compensate metabolic acidosis associated uremia. Indications: United increased demand for calcium (the period of intensive growth in children and adolescents, pregnancy, lactation). A small supply of calcium from the diet. Disorders of calcium reabsorption in the renal tubules, hypocalcemia with hypophosphatemia in patients with chronic renal failure and prevention of increased neuromuscular excitability. Comprehensive prevention of osteoporosis. The period of convalescence after fractures and conditions after prolonged immobilization. Supportively colds and allergic diseases. Contraindications: Hypersensitivity to the components of the preparation. Hypercalcemia (in the course of hyperparathyroidism or thyroid gland, hypervitaminosis D, tumors, severe renal failure, sarcoidosis). Severe hypercalciuria. Nephrolithiasis. Do not use in patients treated with digitalis. Undesirable effects:You may experience gastrointestinal disorders (bloating, belching, nausea, abdominal pain). The use of dosages well above the therapeutic doses can lead to hypercalcemia. Interactions: Calcium reduces absorption of tetracycline and fluoride preparations from the gastrointestinal tract - it is recommended to keep a 2-hour interval between administration of the preparation and of these drugs.Increases the toxic effects of digitalis. Weakens the effect of verapamil and other calcium antagonists. Diuretic thiazides increases the risk of hypercalcemia, and osmotic diuretics, furosemide, ethacrynic acid and caffeine increase the urinary excretion of calcium. Glucocorticoids, calcitonin, oxalic acid, phytic acid and phosphates inhibit the absorption of calcium, while citric acid, vitamin D, parathyroid hormone - to facilitate them. Dosage: orally (with food), adult 2-3 times a day, 1-2 capsules. 500 or 1- 3 times daily 1 capsule. 1000 ie. 400-1200 mg Ca daily. Children over 7 years of age and adolescents: 1 capsule. 500 to 3 times per day, ie. to 600 mg per day. The maximum daily dose is 1,200 mg Ca. Notes: In patients with chronic renal failure should be monitored levels of calcium and phosphate in the blood.