НЕЙРОРУБИН / NEURORUBINE 3ml. /5 units ampoules (Very strong vitamin B complex - B1 + B6 + B12)
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Description / Instructions
Pharmacodynamics. B vitamins are components of enzyme systems that regulate protein, lipid and carbohydrate metabolism. Each of the B vitamins plays a specific biological role. Their presence in the body in a balanced amount necessary for normal metabolism and veschestv.Preparat Neyrorubin Neyrorubin Forte - a combination of 3 vitamins in high doses: B1, B6, B12, which play an important role in the nervous system. Each of them is required for optimal metabolism of the nerve cells. After high doses of vitamins simultaneously exert their analgesic deystvie.Farmakokinetika. Water-soluble vitamins are fully absorbed by the body after the / m introduction. The degree of absorption depends on the blood flow rate in place inektsii.Tiamina hydrochloride (vitamin B1) .Chast absorbed Thiamine is involved in the enterohepatic circulation. Key products of excretion of thiamine - tiaminkarbonovaya and Pyramin acid (2,5-dimethyl-4-aminopyrene Idin). In addition, a small amount of thiamine is excreted unchanged vide.Piridoksina hydrochloride (vitamin B6). The body is oxidized to pyridoxal pyridoxine and aminated to pyridoxamine. The condition of its functioning as a coenzyme is phosphorylation CH2OH group in the 5-position, that is, the formation of pyridoxal-5-phosphate (PALP). In the blood 80% bound to protein. Pyridoxine predominantly accumulates in muscle. The main metabolite, which is released - 4 kislota.Tsianokobalamin pyridoxine (vitamin B12). Normally, the absorption of cyanocobalamin limited and depends on the concentration of intrinsic factor. A quantity of vitamin is absorbed in the free state, but a major amount absorbed after binding to intrinsic factor Kastla.Posle gastrointestinal absorption in vitamin B12 enters the blood serum. Vitamin B12 accumulation occurs mainly in the liver. The half-life of blood serum is approximately five days, tissue from the liver - about 1 year.
Oral: Related Tera Pius in such diseases of the nervous system:
Orally Administered orally before or during a meal, without chewing, drinking plenty of water.The usual dose for adults is 1-2 tablets per day. The course of treatment - 4 weeks. Treatment can be continued at the discretion of vracha.Parenteralno In severe disease dose for adults is: at the beginning of use - 3ml r-ra (the contents of 1 ampoule) in the / m daily or every other day to reduce the severity of pain; in the future - at 3 ml solution of 1-2 times a nedelyu.Pri disease of moderate severity adult dose is 3 ml solution of 1-2 times a nedelyu.Vvodyat / m in the outer upper quadrant of the gluteal myshtsy.Prodolzhitelnost treatment depends on the nature and course of the disease and determined vrachom.Tehnika applications: to open the ampoule, it is necessary to keep up a vial labeled as a point; shake it, until the fluid will be in the lower part;break off the ampoule head over the mark.
Hypersensitivity to one or more components of the drug, especially vitamins B1, B6 or B12. The use of vitamin B12 in patients with psoriasis can lead to poor zabolevaniya.Preparat symptoms in the form of p-ra for Injection is contraindicated in children.
The immune system. Noted isolated cases of angioneurotic edema, predominantly in patients with hypersensitivity; Infrequent - allergic reactions. In individual cases and under certain conditions the repeated / m injection preparations containing vitamins, can cause anaphylactoid reactions in sensitized patients. In these cases, the treatment can be used corticosteroids and antihistamines sredstva.Endokrinnaya system. Before the drug inhibited the selection prolaktina.Nervnaya system. In some cases, the feeling bespokoystva.Pri high doses of pyridoxine hydrochloride (500 mg daily) for a long period, noted some cases of reversible peripheral sensory neyropatii.Serdechno-vascular system. Individual cases of tachycardia, qirkulyatornogo collapse, primarily in patients with elevated chuvstvitelnostyu.Organy breathing.Isolated cases of cyanosis, pulmonary edema, predominantly in patients with increased gastrointestinal chuvstvitelnostyu.Organy. Nausea, bleeding from the gastrointestinal tract, mainly in patients with elevated chuvstvitelnostyu.Pechen and gallbladder. High doses of the drug can lead to increased levels of glutamic oxaloacetic transaminase (SGOT) in krovi.Kozha plasma. It noted some cases of reactions to the appearance of pruritus and urticaria, predominantly in patients with hypersensitivity. High doses of the drug can cause the appearance of acne. Pyridoxine hydrochloride can induce the occurrence of acne. Uncommon - Allergic reaktsii.Obschie symptoms. Sudden sweating, feeling of weakness, dizziness.
Use during pregnancy and lactation. Clinical trials of the drug in animals or in pregnant women have not performed. Vitamin B6 passes into breast milk and placental barer.Sposobnost affect the rate of reaction s when driving and operating other machines. Research on the effect of the drug on to drive a car or other mechanisms not provodili.Deti. No experience with this drug in children.
as pyridoxine hydrochloride, in high doses promotes decarboxylation L-dopamine (levodopa) and may reduce the therapeutic effect of the drug in the treatment of patients with Parkinson's disease, it is necessary to exclude the simultaneous use of these drugs. Isoniazid may increase the toxicity of the combined use. Thiosemicarbazone and Flu orouratsil reduce the effectiveness of vitamin B1, being its antagonists. Antacids slow down the absorption of vitamin B1. Vitamin B6 may reduce its effectiveness altretamina.Nesovmestimost. Due to the lack of research on the compatibility of medicines Neyrorubin in the form of p-ra injection should not be mixed with other drugs.
therapy for intoxication: cause vomiting, stomach is washed, take activated ugol.V rare cases excess daily doses of vitamin B6 (500 mg or more for> 5 months) lead to the development of peripheral sensory neuropathy, which usually disappears after discontinuation of the drug .
pills - in a dry place at temperatures up to 25 ° C; rr - at 2-8 ° C (in a refrigerator).